ATPBD3 Rabbit Polyclonal Antibody

Function:Plays a central role in 2-thiolation of mcm (5) S (2) U at tRNA wobble positions of tRNA (Lys), tRNA (Glu) and tRNA (Gln) . Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position., pathway:tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis., similarity:Belongs to the ttcA family. CTU1/NCS6/ATPBD3 subfamily., subunit:Component of a complex at least composed of URM1, CTU2/NCS2 and ATPBD3/NCS6. May for a heterodimer with CTU2/NCS2., function:Plays a central role in 2-thiolation of mcm (5) S (2) U at tRNA wobble positions of tRNA (Lys), tRNA (Glu) and tRNA (Gln) . Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position., pathway:tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis., similarity:Belongs to the ttcA family. CTU1/NCS6/ATPBD3 subfamily., subunit:Component of a complex at least composed of URM1, CTU2/NCS2 and ATPBD3/NCS6. May for a heterodimer with CTU2/NCS2.

CTU1; ATPBD3; NCS6; Cytoplasmic tRNA 2-thiolation protein 1; ATP-binding domain-containing protein 3; Cancer-associated gene protein; Cytoplasmic tRNA adenylyltransferase 1