ABCC12 Rabbit Polyclonal Antibody

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008], developmental stage:Expressed in fetal tissues., function:Probable transporter., similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily., similarity:Contains 2 ABC transmembrane type-1 domains., similarity:Contains 2 ABC transporter domains., tissue specificity:Expressed in testis (at protein level) . Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells.