ALDH3A1 Rabbit Polyclonal Antibody

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008], catalytic activity:An aldehyde + NAD (P) (+) + H (2) O = an acid + NAD (P) H., function:ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes., similarity:Belongs to the aldehyde dehydrogenase family., subunit:Homodimer., tissue specificity:High levels in stomach, esophagus and lung; low level in the liver and kidney.

Glycolysis / Gluconeogenesis; Histidine metabolism; Tyrosine metabolism; Phenylalanine metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism