A Cyclase IV Rabbit Polyclonal Antibody

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP) . Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010], catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate., cofactor:Binds 2 magnesium ions per subunit., enzyme regulation:Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex., function:This is a membrane-bound, calmodulin-insensitive adenylyl cyclase., similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family., similarity:Contains 2 guanylate cyclase domains.

Purine metabolism; Calcium; Chemokine; Oocyte meiosis; Vascular smooth muscle contraction; Gap junction; Taste transduction; GnRH; Progesterone-mediated oocyte maturation; Melanogenesis; Dilated cardiomyopathy