Cdc23 Rabbit Polyclonal Antibody

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008], function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle., pathway:Protein modification; protein ubiquitination., PTM:Phosphorylated. Phosphorylation on Thr-556 occurs specifically during mitosis., similarity:Belongs to the APC8/CDC23 family., similarity:Contains 9 TPR repeats., subunit:The APC/C is composed of at least 11 subunits.