MACC1 Rabbit Polyclonal Antibody
Product Specifications
Background
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409) -HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]) .[supplied by OMIM, Mar 2009], function:Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF) -dependent scattering in vitro and tumor growth and metastasis in vivo., similarity:Contains 1 SH3 domain., subcellular location:Mainly found in the cytoplasm in non-metastasizing tumors., tissue specificity:Preferentially expressed in metastasizing tumors.
Product Name Alternative
MACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5
Gene Name
MACC1
Gene ID
346389
Swiss Prot
Q6ZN28
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, ELISA
Purification
Affinity purification
Dilution
WB 1:500-1:2000, ELISA 1:10000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
97kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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