MACC1 Rabbit Polyclonal Antibody

MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409) -HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]) .[supplied by OMIM, Mar 2009], function:Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF) -dependent scattering in vitro and tumor growth and metastasis in vivo., similarity:Contains 1 SH3 domain., subcellular location:Mainly found in the cytoplasm in non-metastasizing tumors., tissue specificity:Preferentially expressed in metastasizing tumors.