ICAM-1 (phospho Tyr512) Rabbit Polyclonal Antibody

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008], function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) . During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus., online information:ICAM-1, online information:Icosahedral capsid structure, online information:Intercellular adhesion molecule entry, polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria., PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis., similarity:Belongs to the immunoglobulin superfamily. ICAM family., similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains., subunit:Homodimer (Probable) . Interacts with human herpesvirus 8 MIR2 protein (Probable) . Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.