PARP-4 Rabbit Polyclonal Antibody

This gene encodes poly (ADP-ribosyl) transferase-like 1 protein, which is capable of catalyzing a poly (ADP-ribosyl) ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008], catalytic activity:NAD (+) + (ADP-D-ribosyl) (n) -acceptor = nicotinamide + (ADP-D-ribosyl) (n+1) -acceptor., similarity:Contains 1 BRCT domain., similarity:Contains 1 PARP alpha-helical domain., similarity:Contains 1 PARP catalytic domain., similarity:Contains 1 VWFA domain., subcellular location:Also found in the nucleus, associated with mitotic spindles., subunit:Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs) . Binds to MVP. Associates with TEP1., tissue specificity:Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.

PARP4; ADPRTL1; KIAA0177; PARPL; Poly [ADP-ribose] polymerase 4; PARP-4; 193 kDa vault protein; ADP-ribosyltransferase diphtheria toxin-like 4; ARTD4; PARP-related/IalphaI-related H5/proline-rich; PH5P; Vault poly (ADP-ribose) polymerase; VP