CD297 Rabbit Polyclonal Antibody

This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008], catalytic activity:NAD (+) + protein-L-arginine = nicotinamide + N (omega) - (ADP-D-ribosyl) -protein-L-arginine., catalytic activity:NADP (+) + protein-L-arginine = nicotinamide + N (omega) - ((2'-phospho-ADP) -D-ribosyl) -protein-L-arginine., online information:Blood group antigen gene mutation database, polymorphism:DO is responsible for the Dombrock blood group system. The molecular basis of the Do (a) /Do (b) blood group antigen is a single variation in position 265; Asn-265 corresponds to Do (a) and Asp-265 to Do (b) . It is also responsible for the antigens Gregory [Gy (a) ], Holley [Hy] and Joseph [Jo (a) ]., similarity:Belongs to the Arg-specific ADP-ribosyltransferase family., tissue specificity:Expressed in spleen and T-cells.

Ecto-ADP-ribosyltransferase 4 (EC 2.4.2.31; ADP-ribosyltransferase C2 and C3 toxin-like 4; ARTC4; Dombrock blood group carrier molecule; Mono (ADP-ribosyl) transferase 4; NAD (P) (+) --arginine ADP-ribosyltransferase 4; CD antigen CD297)