CLIC6 Rabbit Polyclonal Antibody

Chloride intracellular channel 6 (CLIC6) Homo sapiens This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015], domain:Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion., function:May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport., PTM:Phosphorylated., similarity:Belongs to the chloride channel CLIC family., similarity:Contains 1 GST C-terminal domain., subcellular location:Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane., subunit:Interacts with dopamine receptors DRD2, DRD3 and DRD4., tissue specificity:Expressed in brain, placenta, pancreas and liver.