NKp30 Rabbit Polyclonal Antibody

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010], function:Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis., polymorphism:A genetic variation in NCR3 is associated with mild malaria suceptibility [MIM:609148]., similarity:Belongs to the natural cytotoxicity receptor (NCR) family., similarity:Contains 1 Ig-like (immunoglobulin-like) domain., subunit:Interacts with CD3Z., tissue specificity:Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.

NCR3; 1C7; LY117; Natural cytotoxicity triggering receptor 3; Activating natural killer receptor p30; Natural killer cell p30-related protein; NK-p30; NKp30; CD antigen CD337