TPH1 (phospho Ser260) Rabbit Polyclonal Antibody
Product Specifications
Background
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009], catalytic activity:L-tryptophan + tetrahydrobiopterin + O (2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin., cofactor:Fe (2+) ion., pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2., similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family., similarity:Contains 1 ACT domain., subunit:Multimer of identical subunits., tissue specificity:Isoform 2 seems to be less widely expressed than isoform 1.
Product Name Alternative
TPH1; TPH; TPRH; TRPH; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1
Gene Name
TPH1
Gene ID
7166
Swiss Prot
P17752
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
Tryptophan metabolism
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Phosphorylated
Molecular Weight
55kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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