Epsin 1 Rabbit Polyclonal Antibody

This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016], domain:The DPW repeat domain is involved in AP2A2 and clathrin binding., domain:The NPF repeat domain is involved in EPS15 binding., function:Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns (4,5) P2) . Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity) . Regulates receptor-mediated endocytosis., online information:The bubble's bend -Issue 42 of January 2004, PTM:Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation., PTM:Ubiquitinated., similarity:Belongs to the epsin family., similarity:Contains 1 ENTH (epsin N-terminal homology) domain., similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats., subcellular location:Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145., subunit:Monomer. Binds clathrin, ZBTB16/ZNF145 and ITSN1. Binds ubiquitinated proteins (By similarity) . Binds REPS2, EPS15, AP2A1 and AP2A2. Interacts with RALBP1 in a complex also containing NUMB and TFAP2A during interphase and mitosis.