DGK-β Rabbit Polyclonal Antibody

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD) . The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008], catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate., enzyme regulation:Stimulated by phosphatidylserine., function:Exhibits high phosphorylation activity for long-chain diacylglycerols., similarity:Belongs to the eukaryotic diacylglycerol kinase family., similarity:Contains 1 DAGKc domain., similarity:Contains 2 EF-hand domains., similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.