CHP2 Rabbit Polyclonal Antibody

This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988) . This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013], function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death., similarity:Contains 4 EF-hand domains., subunit:Binds to SLC9A1/NHE1., tissue specificity:Expressed in malignantly transformed cells but not detected in normal tissues.

MAPK_ERK_Growth; MAPK_G_Protein; Calcium; Oocyte meiosis; Apoptosis_Inhibition; Apoptosis_Mitochondrial; Apoptosis_Overview; WNT; WNT-T CELLAxon guidance; VEGF; Natural killer cell mediated cytotoxicity; T_Cell_Receptor; B_Cell_Antigen; Long-term potentiation; Alzheimer's disease; Amyotrophic lateral sclerosis (ALS)