LEF-1 (phospho Ser42) Rabbit Polyclonal Antibody

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009], alternative products:Additional isoforms seem to exist, domain:Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors., function:Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity) . Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling., similarity:Belongs to the TCF/LEF family., similarity:Contains 1 HMG box DNA-binding domain., subcellular location:Found in nuclear bodies upon PIASG binding., subunit:Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity) . Binds THOC4, MDFI and MDFIC., tissue specificity:Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines.

WNT; WNT-T CELLAdherens_Junction; Melanogenesis; Pathways in cancer; Colorectal cancer; Endometrial cancer; Prostate cancer; Thyroid cancer; Basal cell carcinoma; Acute myeloid leukemia; Arrhythmogenic right ventricular cardiomyopathy (ARVC)