CD28 (phospho Tyr218) Rabbit Polyclonal Antibody

The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011], function:Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival., online information:CD28 entry, similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain., subunit:Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70., tissue specificity:Expressed in T-cells and plasma cells, but not in less mature B-cells.

Cell adhesion molecules (CAMs) ; T_Cell_Receptor; Intestinal immune network for IgA production; Type I diabetes mellitus; Autoimmune thyroid disease; Systemic lupus erythematosus; Allograft rejection; Graft-versus-host disease; Viral myocarditis