ZIP1 Rabbit Polyclonal Antibody

This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012], function:Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells., miscellaneous:Inhibited by Ni (2+) ions. Fe (2+) ions do not inhibit zinc uptake., similarity:Belongs to the ZIP transporter (TC 2.A.5) family., subcellular location:Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines., tissue specificity:Ubiquitous. Expressed in most adult and fetal tissues including the epidermis.

SLC39A1; IRT1; ZIP1; ZIRTL; CGI-08; CGI-71; Zinc transporter ZIP1; Solute carrier family 39 member 1; Zinc-iron-regulated transporter-like; Zrt- and Irt-like protein 1; ZIP-1; hZIP1