CNOT2 (phospho Ser101) Rabbit Polyclonal Antibody

CCR4-NOT transcription complex subunit 2 (CNOT2) Homo sapiens This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010], function:The CCR4-NOT complex functions as general transcription regulation complex., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the CNOT2/3/5 family., subunit:Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8., tissue specificity:Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.