GRK 2 (phospho Ser685) Rabbit Polyclonal Antibody

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008], catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate., catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them., online information:Beta adrenergic receptor kinase entry, similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 PH domain., similarity:Contains 1 protein kinase domain., similarity:Contains 1 RGS domain., subunit:Interacts with GIT1 (By similarity) . Interacts with, and phosphorylates chemokine-stimulated CCR5., tissue specificity:Expressed in peripheral blood leukocytes.