TNNI3K Rabbit Polyclonal Antibody

This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012], catalytic activity:ATP + a protein = ADP + a phosphoprotein., catalytic activity:GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose., cofactor:Magnesium., function:Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids., function:May play a role in cardiac physiology., PTM:Autophosphorylated., similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 10 ANK repeats., subcellular location:Expressed at lower levels in the cytoplasm., subunit:Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB., tissue specificity:Expressed in many tissues., tissue specificity:Highly expressed in both adult and fetal heart.