GM2/GD2 synthase Rabbit Polyclonal Antibody

Beta-1,4-N-acetyl-galactosaminyltransferase 1 (B4GALNT1) Homo sapiens GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G (M2) and G (D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G (M3) and G (D3) by a beta-1,4 linkage, resulting in the synthesis of G (M2) and G (D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013], catalytic activity:UDP-N-acetyl-D-galactosamine + 1-O- (O- (N-acetyl-alpha-neuraminosyl) - (2->3) -O-beta-D-galactopyranosyl- (1->4) -beta-D-glucopyranosyl) -ceramide = UDP + 1-O- (O-2- (acetylamino) -2-deoxy-beta-D-galactopyranosyl- (1->4) -O- (N-acetyl-alpha-neuraminosyl- (2->3) ) -O-beta-D-galactopyranosyl- (1->4) -beta-D-glucopyranosyl) -ceramide., function:Involved in the biosynthesis of gangliosides GM2, GD2 and GA2., online information:Beta-1,4 N-acetylgalactosaminyltransferase 1, online information:GlycoGene database, pathway:Protein modification; protein glycosylation., similarity:Belongs to the glycosyltransferase 2 family., subunit:Homodimer; disulfide-linked.