GAP-43 Rabbit Polyclonal Antibody
Product Specifications
Background
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008], function:This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons., online information:Gap-43 entry, PTM:Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity., similarity:Belongs to the neuromodulin family., similarity:Contains 1 IQ domain., subcellular location:Cytoplasmic surface of growth cone and synaptic plasma membranes., subunit:Binds calmodulin with a greater affinity in the absence of Ca (2+) than in its presence.
Product Name Alternative
GAP43; Neuromodulin; Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46
Gene Name
GAP43
Gene ID
2596
Swiss Prot
P17677
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:10000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
43kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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