E4BP4 Rabbit Polyclonal Antibody

The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014], function:Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity) . Represses transcriptional activity of PER1 (By similarity) . Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity) . Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity) . Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity) . Protects pro-B cells from programmed cell death., induction:Up-regulated by PHA or TPA., similarity:Belongs to the bZIP family. NFIL3 subfamily., similarity:Contains 1 bZIP domain., subunit:Homodimer. Binds DNA as a dimer. Interacts with DR1. Interacts with PER2 and CRY2., tissue specificity:Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and muscle.

NFIL3; E4BP4; IL3BP1; Nuclear factor interleukin-3-regulated protein; E4 promoter-binding protein 4; Interleukin-3 promoter transcriptional activator; Interleukin-3-binding protein 1; Transcriptional activator NF-IL3A