CNOT4 Rabbit Polyclonal Antibody

CCR4-NOT transcription complex subunit 4 (CNOT4) Homo sapiens The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010], function:Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex., pathway:Protein modification; protein ubiquitination., PTM:Autoubiquitinated., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., sequence caution:Sequencing errors., similarity:Contains 1 C3H1-type zinc finger., similarity:Contains 1 RING-type zinc finger., similarity:Contains 1 RRM (RNA recognition motif) domain., subunit:Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Binds CNOT1 via its C-terminus. Binds E2 ubiquitin ligases via its RING domain.

CNOT4; NOT4; CCR4-NOT transcription complex subunit 4; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; Potential transcriptional repressor NOT4Hp