PDK1 Rabbit Polyclonal Antibody
Product Specifications
Background
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013], catalytic activity:ATP + [pyruvate dehydrogenase (acetyl-transferring) ] = ADP + [pyruvate dehydrogenase (acetyl-transferring) ] phosphate., function:Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism., similarity:Belongs to the PDK/BCKDK protein kinase family., similarity:Contains 1 histidine kinase domain., tissue specificity:Expressed predominantly in the heart.
Product Name Alternative
PDK1; PDHK1; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; mitochondrial; Pyruvate dehydrogenase kinase isoform 1
Gene Name
PDK1
Gene ID
5163
Swiss Prot
Q15118
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC
Field of Research
T_Cell_Receptor; Fc epsilon RI; Neurotrophin
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:50-1:300
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
50kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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