Epsin 2 Rabbit Polyclonal Antibody

This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data., domain:The DPW repeat domain is involved in AP-2 and clathrin binding., domain:The NPF repeat domain is involved in EPS15 binding., function:Plays a role in the formation of clathrin-coated invaginations and endocytosis., PTM:Ubiquitinated., similarity:Belongs to the epsin family., similarity:Contains 1 ENTH (epsin N-terminal homology) domain., similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats., subcellular location:In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex., subunit:Binds EPS15 (By similarity) . Binds AP-2 and clathrin., tissue specificity:Highest expression is found in brain. Detected at lower levels in lung and liver.