CstF-50 Rabbit Polyclonal Antibody

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF) . CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008], domain:N-terminus mediates homodimerization., domain:The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3., function:One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA., PTM:The N-terminus is blocked., similarity:Contains 6 WD repeats., subunit:Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit) . Interacts directly with CSTF3. Interacts with BARD1.