CNK2 Rabbit Polyclonal Antibody

This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009], function:May function as an adapter protein or regulator of Ras signaling pathways., PTM:Phosphorylated on tyrosine., similarity:Belongs to the CNKSR family., similarity:Contains 1 CRIC domain., similarity:Contains 1 DUF1170 domain., similarity:Contains 1 PDZ (DHR) domain., similarity:Contains 1 PH domain., similarity:Contains 1 SAM (sterile alpha motif) domain., subunit:Interacts with RAF1, RAB2L and RAL GTPase proteins.