WTAP Rabbit Polyclonal Antibody
Product Specifications
Background
The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012], function:Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation., induction:In smooth muscle cells, up-regulated after serum withdrawal, when cells become mature and non proliferative., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the fl (2) d family., subunit:Interacts with WT1., tissue specificity:Ubiquitously expressed.
Product Name Alternative
WTAP; KIAA0105; Pre-mRNA-splicing regulator WTAP; Female-lethal (2) D homolog; hFL (2) D; WT1-associated protein; Wilms tumor 1-associating protein
Gene Name
WTAP
Gene ID
9589
Swiss Prot
Q15007
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:10000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
55kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Product Datasheet
https://assets.enkilife.com/files/antibody/APRab19938_Enkilife_EN.pdf
Isotype
IgG
Available Sizes
Curated Selection
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