Sp2 Rabbit Polyclonal Antibody

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008], function:Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites., similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family., similarity:Contains 3 C2H2-type zinc fingers.