GRB14 Rabbit Polyclonal Antibody

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014], function:Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor which is then inhibited. The interaction is mediated by the SH2 domain., PTM:Phosphorylated on serine residues., similarity:Belongs to the GRB7/10/14 family., similarity:Contains 1 PH domain., similarity:Contains 1 Ras-associating domain., similarity:Contains 1 SH2 domain., subunit:Binds to the ankyrin repeat region of TNKS2 via its N-terminus., tissue specificity:Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.