NEIL3 Rabbit Polyclonal Antibody
Product Specifications
Background
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]) .[supplied by OMIM, Mar 2008], function:Reports about DNA glycosylase activity are contradictory. The protein lacks a proline residue at the N-terminus that is the active site residue found in the other members of the FPG family., similarity:Belongs to the FPG family., similarity:Contains 1 FPG-type zinc finger., similarity:Contains 1 RanBP2-type zinc finger., tissue specificity:Detected in thymus and testis.
Product Name Alternative
NEIL3; Endonuclease 8-like 3; DNA glycosylase FPG2; DNA glycosylase/AP lyase Neil3; Endonuclease VIII-like 3; Nei-like protein 3
Gene Name
NEIL3
Gene ID
55247
Swiss Prot
Q8TAT5
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
Base excision repair
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:20000-1:40000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
35kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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