PPP1R14D Rabbit Polyclonal Antibody

Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]) .[supplied by OMIM, Feb 2010], function:Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction., PTM:Phosphorylated on several residues., similarity:Belongs to the PP1 inhibitor family., tissue specificity:Detected in colon, intestine, kidney and brain cortex.