IGF-I Rabbit Polyclonal Antibody

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015], disease:Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation., function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity., online information:Insulin-like growth factor 1 entry, online information:The Singapore human mutation and polymorphism database, similarity:Belongs to the insulin family.

Oocyte meiosis; p53; mTOR; Focal adhesion; Long-term depression; Progesterone-mediated oocyte maturation; Aldosterone-regulated sodium reabsorption; Pathways in cancer; Glioma; Prostate cancer; Melanoma; Hypertrophic cardiomyopathy (HCM) ; Dilated cardiomyopathy