CDHF10 Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008], function:Receptor that may have an important role in cell/cell signaling during nervous system formation., PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains., similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily., similarity:Contains 1 GPS domain., similarity:Contains 1 laminin EGF-like domain., similarity:Contains 2 laminin G-like domains., similarity:Contains 7 EGF-like domains., similarity:Contains 9 cadherin domains., tissue specificity:Highest expression in brain and testis.

CELSR2; CDHF10; EGFL2; KIAA0279; MEGF3; Cadherin EGF LAG seven-pass G-type receptor 2; Cadherin family member 10; Epidermal growth factor-like protein 2; EGF-like protein 2; Flamingo homolog 3; Multiple epidermal growth factor-like domains