BMP-1 Rabbit Polyclonal Antibody

This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008], catalytic activity:Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III., cofactor:Binds 1 zinc ion per subunit., enzyme regulation:Activity is increased by the procollagen C-endopeptidase enhancer protein., function:Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD) ., similarity:Belongs to the peptidase M12A family., similarity:Contains 2 EGF-like domains., similarity:Contains 5 CUB domains., tissue specificity:Ubiquitous.