RSK3 Rabbit Polyclonal Antibody

Ribosomal protein S6 kinase A2 (RPS6KA2) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016], catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues., function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB., PTM:Autophosphorylated on Ser-377, as part of the activation process., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 2 protein kinase domains., subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation., tissue specificity:Expressed in many tissues. Highest expression in lung and skeletal muscle.