OY-TES-1 Rabbit Polyclonal Antibody

The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008], function:May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin., PTM:Phosphorylated on Tyr residues in capacitated sperm., PTM:The N-terminus is blocked., subcellular location:Colocalizes with proacrosin in the acrosome of sperm., subunit:Binds proacrosin., tissue specificity:Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.