HMG-2 Rabbit Polyclonal Antibody

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V (D) J recombination. [provided by RefSeq, Jul 2008], function:Binds preferentially single-stranded DNA and unwinds double stranded DNA., similarity:Belongs to the HMGB family., similarity:Contains 2 HMG box DNA-binding domains., subunit:Component of the SET complex, which also contains SET, ANP32A, APEX1 and NME1. Directly interacts with SET.