AAK1 Rabbit Polyclonal Antibody

Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008], catalytic activity:ATP + a protein = ADP + a phosphoprotein., enzyme regulation:Stimulated by clathrin., function:Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) . May play a role in regulating aspects of clathrin-mediated endocytosis., PTM:Autophosphorylated., similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family., similarity:Contains 1 protein kinase domain., subcellular location:Active when found in clathrin-coated pits at the plasma membrane., subunit:Interacts with alpha-adaptin and AP-2.