PI 3-Kinase p110δ Rabbit Polyclonal Antibody

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010], catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate., pathway:Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis., PTM:Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity., similarity:Belongs to the PI3/PI4-kinase family., similarity:Contains 1 PI3K/PI4K domain., subunit:Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Interacts with ERAS., tissue specificity:Expressed predominantly in leukocytes.

PIK3CD; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; PI3-kinase subunit delta; PI3K-delta; PI3Kdelta; PtdIns-3-kinase subunit delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PtdIns-3-kinase subunit p110-delta; p110delta

Inositol phosphate metabolism; ErbB_HER; Chemokine; Phosphatidylinositol signaling system; mTOR; Apoptosis_Inhibition; Apoptosis_Mitochondrial; Apoptosis_Overview; VEGF; Focal adhesion; Toll_Like; Jak_STAT; Natural killer cell mediated cytotoxicity; T_Cell_Receptor; B_Cell_Antigen; Fc epsilon RI; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Neurotrophin; Regulates Actin and Cytoskeleton; Insulin_Receptor; Progesterone-mediated oocyte maturation; Type II diabetes mellitus; Aldosterone-regulated sodium reabsorption; Pathways in cancer; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer