DUS2L Rabbit Polyclonal Antibody

Dihydrouridine synthase 2 (DUS2) Homo sapiens This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012], cofactor:FAD., function:Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs., similarity:Belongs to the dus family. Dus2 subfamily., similarity:Contains 1 DRBM (double-stranded RNA-binding) domain., subcellular location:Mainly at the endoplasmic reticulum., subunit:Interacts with EPRS., tissue specificity:Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level) .

DUS2L; DUS2; tRNA-dihydrouridine (20) synthase [NAD (P) +]-like; Up-regulated in lung cancer protein 8; URLC8; tRNA-dihydrouridine synthase 2-like; hDUS2