CARD 11 Rabbit Polyclonal Antibody

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD) . This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008], caution:Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART., function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10., similarity:Contains 1 CARD domain., similarity:Contains 1 guanylate kinase-like domain., similarity:Contains 1 PDZ (DHR) domain., subunit:CARD11 and BCL10 bind to each other by CARD-CARD interaction., tissue specificity:Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.