NT5C1A Rabbit Polyclonal Antibody

Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]) .[supplied by OMIM, Mar 2008], catalytic activity:A 5'-ribonucleotide + H (2) O = a ribonucleoside + phosphate., cofactor:Magnesium., enzyme regulation:Activated by ADP., function:Dephosphorylates the 5' and 2' (3') -phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia., similarity:Belongs to the 5'-nucleotidase type 3 family., tissue specificity:Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.