PUMA Rabbit Polyclonal Antibody

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011], function:Essential mediator of p53-dependent and p53-independent apoptosis., induction:By DNA damage, glucocorticoid treatment, growth factor deprivation and p53., similarity:Belongs to the Bcl-2 family., subcellular location:Localized to the mitochondria in order to induce cytochrome c release., subunit:Interacts with MCL1 and BCL2A1 (By similarity) . Interacts with BCL2 and BCL2L1/BCL-XL., tissue specificity:Ubiquitously expressed.