RBAK Rabbit Polyclonal Antibody

This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011], function:May repress E2F-dependent transcription. May promote AR-dependent transcription., similarity:Belongs to the krueppel C2H2-type zinc-finger protein family., similarity:Contains 1 KRAB domain., similarity:Contains 16 C2H2-type zinc fingers., subunit:Interacts with AR and RB1. May also interact with other nuclear hormone receptors such as NR3C1/GR., tissue specificity:Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.