Rit1 Rabbit Polyclonal Antibody

This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012], enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP., function:Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation., miscellaneous:Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members., miscellaneous:Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation., similarity:Belongs to the small GTPase superfamily. Ras family., subunit:Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state. Interacts with RGL3., tissue specificity:Expressed in many tissues.