SNAT2 Rabbit Polyclonal Antibody

Enzyme regulation:Inhibited by N-methyl-D-glucamine and probably choline., function:Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta., induction:Up-regulated upon hypertonic conditions and amino acid deprivation., miscellaneous:Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress., PTM:Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2., similarity:Belongs to the amino acid/polyamine transporter 2 family., subcellular location:Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity) . Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal., tissue specificity:Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level) ., enzyme regulation:Inhibited by N-methyl-D-glucamine and probably choline., function:Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta., induction:Up-regulated upon hypertonic conditions and amino acid deprivation., miscellaneous:Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress., PTM:Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2., similarity:Belongs to the amino acid/polyamine transporter 2 family., subcellular location:Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity) . Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal., tissue specificity:Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level) .

SLC38A2; ATA2; KIAA1382; SAT2; SNAT2; Sodium-coupled neutral amino acid transporter 2; Amino acid transporter A2; Protein 40-9-1; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino a